A few weeks ago, GEN presented you with a list of the top 20 biopharma R&D spenders. However, drug discovery is only part of the R&D story; what about the companies that make the technology that makes drug discovery possible? Following is a list of top 25 life sciences tools and technologies providers—including both companies and divisions of broader corporate giants—as ranked by their R&D spending for 2012. Listings include R&D spending for 2012 and 2011, the percentage difference between the two years, the percentage of sales for both years, and 2008 R&D spending and percentage of sales.

#22. Fluidigm

2012 R&D spending: $16.602 million

2011 R&D spending: $13.936 million

% Change: 19.1%

2012 percentage of revenues: 31.7%

2011 percentage of revenues: 32.5%

#21. Eppendorf International

2012 R&D spending: $35.233 million(€27.5 million)^1,2

2011 R&D spending: $31.823 million(€24.838 million)²

% Change: 10.7%

2012 percentage of sales: 5.3%

2011 percentage of sales: 5.2%

#20. Sartorius Stedim Biotech

2012 R&D spending: $39.683 million(€30.972 million)³

2011 R&D spending: $36.616 million(€28.580 million)³

% Change: 8.4%

2012 percentage of sales revenue: 5.7%

2011 percentage of sales revenue: 6.0%

#19. Sequenom

2012 R&D spending: $54.115 million

2011 R&D spending: $53.585 million

% Change: 1.0%

2012 percentage of revenues: 60.3%

2011 percentage of revenues: 95.8%

#18. Affymetrix

2012 R&D spending: $57.881 million

2011 R&D spending: $63.591 million

% Change: -9.0%

2012 percentage of revenues: 19.6%

2011 percentage of revenues: 23.8%

#17. Sigma-Aldrich

2012 R&D spending: $69 million

2011 R&D spending:$72 million

% Change: 4.2%

2012 percentage of revenues: 2.6%

2011 percentage of revenues: 2.9%

#16. Cepheid

2012 R&D spending: $71.673 million

2011 R&D spending: $59.362 million

% Change: 20.7

2012 percentage of revenues: 21.6%

2011 percentage of revenues: 21.4%

#15. Waters

2012 R&D spending: $96.004 million

2011 R&D spending: $92.347 million

% Change: 4.0%

2012 percentage of net sales: 5.2%

2011 percentage of net sales: 5.0%

#14. Mettler-Toledo International

2012 R&D spending: $112.530 million

2011 R&D spending: $116.139 million

% Change: -3.1%

2012 percentage of net sales: 4.8%

2011 percentage of net sales: 5.0%

#13. Qiagen

2012 R&D spending: $122.476 million

2011 R&D spending: $130.636 million

% Change: -6.2%

2012 percentage of net sales: 9.8%

2011 percentage of net sales: 11.2%

#12. PerkinElmer

2012 R&D spending: $132.639 million

2011 R&D spending: $115.821 million

% Change: 14.5%

2012 percentage of revenues: 6.3%

2011 percentage of revenues: 6.0%

#11. Danaher Life Sciences & Diagnostics⁴

2012 R&D spending: $418 million

2011 R&D spending: $341 million

% Change: 22.6%

2012 percentage of sales: 6.5%

2011 percentage of sales: 7.3%

#10. Bruker

2012 R&D spending: $195.3 million

2011 R&D spending:$177.2 million

% Change: 10.2%

2012 percentage of revenues: 10.9%

2011 percentage of revenues: 10.7%

#9. Merck Millipore⁵

2012 R&D spending: $212.890 million(€166.1 million)⁶

2011 R&D spending: $170.978 million(€133.4 million)^6,7

% Change: 24.5%

2012 percentage of sales: 6.4%

2011 percentage of sales: 5.6%

#8. Bio-Rad Laboratories

2012 R&D spending: $214.040 million

2011 R&D spending: $186.439 million

% Change: 14.8%

2012 percentage of net sales: 10.3%

2011 percentage of net sales: 9.0%

#7. Illumina

2012 R&D spending: $231.025 million

2011 R&D spending: $196.913 million

% Change: 17.3%

2012 percentage of revenues: 20.1%

2011 percentage of revenues: 18.7%

#6. Thermo Fisher Scientific

2012 R&D spending: $376.4 million

2011 R&D spending:$340.2 million

% Change: 10.6%

2012 percentage of revenues: 3.0%

2011 percentage of revenues: 2.9%

#5. Life Technologies

2012 R&D spending: $341.892 million

2011 R&D spending: $377.924 million

% Change: -9.5%

2012 percentage of revenues: 9.0%

2011 percentage of revenues: 10.0%

#4. Becton Dickinson (BD)

2012 R&D spending: $471.755 million⁸

2011 R&D spending:$469.517 million⁸

% Change: 0.5%

2012 percentage of revenues: 6.1%

2011 percentage of revenues: 6.2%

#3. Agilent Technologies

2012 R&D spending: $668 million⁹

2011 R&D spending: $649 million⁹

% Change: 2.9%

2012 percentage of net revenues: 9.7%

2011 percentage of net revenues: 9.5%

#2. GE Healthcare¹⁰

2012 R&D spending: Approx. $1 billion¹¹

2011 R&D spending: Approx. $1 billion¹¹

% Change: No change

2012 percentage of revenues: about 5.5%

2011 percentage of revenues: about 5.5%

#1. Roche - Diagnostics Division¹²

2012 R&D spending: $1.078 billion(CHF 1.023 billion)¹³

2011 R&D spending: $978.914 million(CHF 929 million)¹³

% Change: 10.1%

2012 percentage of sales: 10.0%

2011 percentage of sales: 9.5%

（来源：GEN）